HemoDynamic Info

The evidence

Peer-reviewed. Published. Being tested further.

Featured study

Published in the American Journal of Medicine.

Title, authors and abstract of the Cleland 2026 American Journal of Medicine study

Cleland JGF, Romer DE, et al. Effect of routinely tailoring anti-hypertensive therapy to hemodynamic profile in primary care. American Journal of Medicine, 2026.

14,058

primary-care patients

10 years, two US groups

74%

controlled at first follow-up

~30 days, lead site, <140/90

92%

controlled by second follow-up

lead site, <140/90

~90%

control held across racial groups

47% / 24% / 29%

vasoconstriction / hyperdynamic / mixed patients

Limitations, in plain English

Observational, not randomized.
Funded by IMS and MedsEngine.
NICaS was used with MedsEngine decision support inside a managed quality program.
The control target was <140/90.

Next: a US randomized trial

HDI plans a randomized controlled trial at a US academic medical center, running alongside launch.

Study library

Published research using NICaS.

Hypertension

Effect of routinely tailoring anti-hypertensive therapy to hemodynamic profile in primary care

Cleland JGF, Romer DE, et al.

American Journal of Medicine, 2026

Observational study of 14,058 primary-care patients across two US groups over 10 years; industry-funded by IMS and MedsEngine.

Pregnancy

The effect of impedance cardiography directed antihypertensive therapy on fetal growth restriction rates and perinatal mortality in women with chronic hypertension

Cottrell J, Cummings K, Jude D, Chaffin D

Pregnancy Hypertension 28:123–127, 2022

Pregnancy

Maternal cardiovascular hemodynamics in normotensive versus preeclamptic pregnancies (NICaS)

Lavie A, Ram M, et al.

BMC Pregnancy and Childbirth 18:229, 2018

Pregnancy

Hemodynamics of labor in women undergoing vaginal and cesarean deliveries

Ashwal E, Shinar S, et al.

2017

Pregnancy

Cardiac hemodynamics before, during and after elective cesarean delivery

Lavie A, Ram M, et al.

AJOG (abstract), 2016

Pregnancy

Cardiac index in pregnancy: friend or foe

Ram M, Lavie A, et al.

AJOG (abstract), 2016

Pregnancy

Cardiac hemodynamics in labor and postpartum: a new look into physiology

Ashwal E, Hiersch L, et al.

AJOG (abstract), 2015

Regulatory

NICaS is FDA-cleared (510(k)). HDI describes NICaS only within its cleared indication.

510(k) number: [to be added]

News & insights

From the HDI team.

Coming soon.

Cleland et al., Am J Med 2026 (observational, funded by IMS and MedsEngine; lead site, <140/90).

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